Insitu gels. The document reviews various polymer types and approaches .

Insitu gels. Temperature modulation, pH alteration, ions present in the site and ultraviolet irradiation are factors that influence gel formation. Chitosan is a natural polymer suitable for use in ophthalmic formulations due to its biocompatibility, biodegradability, mucoadhesive This review describes in situ gelling systems resulting from the association of chitosan with various stimuli-responsive polymers with emphasis on the mechanism of gel formation and application in ophthalmology. This chapter explores the classification of in situ gel based on stimuli and offers an overview of topical drug administration Dec 1, 2016 · In situ forming hydrogels with simple sol–gel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration. Jan 1, 2009 · The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by use of in –situ gel forming Apr 15, 2020 · The in-situ gelling system is a process in which the solution forms of a gel before administration in the body, but once administrated, it undergoes gelation in-situ, to form a gel. The formulation approaches like temperature intonation, pH change and presence of ions from which the drug gets released during a sustained and controlled manner are used for in-situ gels. Other benefits of these systems include easy production, improved adherence, and ease of use. Oct 9, 2018 · Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged contact time of ointments. Dec 30, 2024 · When injected into the body, these insitu sol-gel transition hydrogels, based on temperature-responsive polymers, form insitu depots at body temperature and allow the sustained release of loaded compounds. Jan 4, 2012 · In situ gel drug delivery systems are used in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. This is because the eyes are sensitive and require careful Mar 1, 2018 · In vivo these gels again displayed higher levels of VEGF and PDGF sequestration than gels which were not crosslinked with heparin, and showed widely distributed vasculature after two weeks, a phenomenon that was absent from all control gels. An in situ gel is drug delivery system that exhibits sol-to-gel phase transi-tion due to change in specific physicochemical parameters such as ionic, temperature or pH. In-situ gel drug delivery are in solution form before administration in the body, but once administered undergoes gelation in-situ, to form gel. The in situ gelation mechanism has several advantages over ointments, the most notable being the ability to provide regular and continuous drug delivery with no impact on visual clarity. It describes various polymers used to form in situ gels via temperature, pH, or ion triggers. Key components include temperature-sensitive, pH-sensitive, ion-sensitive, enzyme-sensitive In Situ Gel/Depot-Forming Drug Products In situ gel/depot-forming drug products are formulations that form a gel/depot at the administration site and exhibit prolonged drug delivery. Schematic representation of the IA administration of an in situ gelling drug formulation into inflamed osteoarthritis (OA) joint and healthy tissue after treatment. The objective of present study was to design, formulate and evaluate ion-activated in situ gel to enhance the ocular penetration and Jan 1, 2025 · The “In situ gel” is a promising drug delivery system characterized by the ability to shift from a liquid to a gel when applied. The formulations were evaluated regarding gelation temperature, pH, viscosity, syringeability study Jan 1, 2022 · Polymeric gels that possess optimal rheological properties could aid in elevating the contact time of the therapeutics with the body mucosa and thereby, enhancing the absorption of poorly available drugs. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can To establish a novel delivery system of pemirolast potassium-loaded gellan gum in situ gel in allergic conjunctivitis therapy. T he ‘in situ gel’ system has emerged as one of the best novel drug delivery systems, the in situ gelling system helps for the sustained and controlled release of the drugs, improved patient compliance and comfort1 by its special characteristic feature of ‘Sol to Gel’ transition. The aim of the present study was to Mar 6, 2015 · Many numbers of in situ gel-forming systems have been investigated, and many copyrights for their use in different biomedical applications, including drug delivery, have been reported (Peppas and Langer 1994). In situ gelling systems are polymeric formulations that are in sol forms before entering in the body, but change to gel forms under the physiological conditions. In situ gel is drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. Ciprofloxacin hydrochloride is popularly used as a broad spectrum antibiotic Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. The formation of gels depends on factors like temperature changes, pH changes, presence of ions and ultraviolet irradiation. Their unique gelling properties endow them with spe … In situ gel system is formulated as liquid preparation suitable to be instilled into eyes which upon exposure to the physiologic environment changes to gel results in in-situ gel, thus increasing the precorneal residence time of the delivery system, and enhances the ocular bioavailability of the drug. Mar 5, 2024 · Both in-situ gels and pre-formed hydrogels are types of hydrogels. When exposed to physiological conditions (e. The direct application of in situ gels offers targeted delivery, few side effects, and self-administration; the review focuses on the benefits, advantages, and disadvantages of in situ gel administration for periodontitis, as well as the characteristics of tooth physiology, preparation techniques, and polymers and biomarkers used. The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease. The modern in situ approach to gel formation is still very rare [38, 39, 40] but should soon see a tremendous increase in popularity considering the advantages already described for these systems [39]. In situ gel-forming drug delivery systems are designed to release drugs in a sustained manner, maintaining a consistent and steady level of the drug in the bloodstream over a prolonged period. Thermosensitive or thermoreversible in situ hydrogel systems are sols below body temperature and turn to gels after administration into the body. In situ gel-forming systems increase the retention of drugs in the nasal cavity, and some of them also show permeation-enhancing capabilities. An in situ gel is drug delivery system that exhibits sol-to-gel phase transition due to change in specific physicochemical parameters such as ionic, temperature or pH. These gels are composed of cross-linked 3D networks of polymers, with hydrogels being a specific type of absorbing water while r … Mar 1, 2013 · The in situ formed gels have been investigated for their potential in various biomedical applications including minimally invasive drug delivery, 3D cell culture, injectable tissue engineering, surgical glues, tissue sealants, and adhesion prevention coating [5], [6], [7]. The ideal critical Jan 19, 2021 · PDF | On Jan 19, 2021, Mandar J. These phase-change polymers, which trigger the drug release in response to … Jun 25, 2024 · Here, the authors report in-situ polymerization to improve the stability of gel polymer Li-ion batteries. 1% w/v Chlorhexidine hydrochloride was formulated by cold method using different polymers. - View online for free Abstract In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in response to various stimuli such as changes in temperature, pH and ionic composition. It also comprises the main techniques for evaluation of chitosan in situ gels, along with requirements of safety and ocular tolerability. In-situ gel is a kind of liquid preparation, which will immediately transform to non-chemically crosslinked semisolid gel in the application site after administration. 'Sol-gel' produces a colloidal suspension or solution by hydrolyzing the precursor Nanoparticles Recently, incorporated in situ gel formulations. Transition from sol to gel is Abstract Background: The thermo-sensitive in situ gels based on copolymers are attractive as an injectable drug delivery carriers for sustained releasing of hydrophilic drugs. This article reviews the in situ gel-forming systems used for nasal drug delivery and introduces their gelling mechanisms and other favorable features for intranasal delivery. Characterization of in situ gel was determined to ensure that Apr 1, 2010 · The in situ gel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery systems. The thermosensitive The review article aims to highlight the recent developments in various in situ gel-forming polymeric systems that are used to achieve prolonged contact time of drugs with the cornea and increase their ocular bioavailability. The potential of i The document discusses in situ gels, which are liquid formulations that transform into gels inside the body. In the last decade in situ gelling systems have emerged as a novel approach in intranasal delivery of therapeutics, capturing the interest of scientific community. After explaining buccal drug delivery and mucoadhesion, various studies with hydrogels, in situ gels, and nanogels were analyzed as buccal gel systems. These systems offer advantages over traditional methods including reduced dosing frequency, controlled drug release, enhanced bioavailability, improved patient compliance, and targeted May 11, 2023 · The in situ ophthalmic gel is a semisolid ophthalmic preparation that can be changed in the eyes immediately after the solution is administered, showing unique advantages as a new drug delivery system. Dual-drug Dusunge Carbohydr evaluation Thiolated as on in situ gel-forming nanosuspension of Feb 1, 2013 · Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. The advent of in situ gel systems has inaugurated a new transom for 'smart' ocular delivery. It also categorizes in situ gel systems based on their gelation mechanism and administration route. These systems have several advantages like simple manufacturing, easy to use, improved adherence, and patient comfort by MECHANISM OF IN SITU GELS In situ formation based on physical mechanism Swelling In situ formation may also occur when material absorbs water from surrounding environment and expand to desired space. Mar 6, 2023 · Many studies have proved that the development of nanoparticle-laden in situ gel had the advantage to improve the ocular bioavailability of water-soluble drugs (Imam et al. In this study, a thermosensitive in situ gel formulation was prepared for Apr 8, 2022 · Abstract In situ gel forming polymeric formulations are drug delivery systems that are in sol form before being administered to the body, but gel in situ from which the medication is released in a sustained and controlled manner. The in situ gel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery systems. Such systems c … In both cases the resulting gels exhibit the same macroscopic and microscopic properties without any loss by the in situ generation of the gel. Jan 9, 2025 · We will talk about the several methods used to create gastro-retention in drug delivery systems with a focus on the floating in-situ gel system for stomach-specific drug administration. The following review presents a brief introduction to in situ gels, various approaches for in situ gelling system, different types of polymers used, their evaluation and applications. In this paper we present recent developments on in situ gelling systems for nasal delivery Mar 30, 2020 · In conclusion, the two thermosensitive in situ gels have prolonged drug release after ocular drug delivery compared with ion exchange resin eye drops, implying their potential applications in clinic with broad drug adoptability. At room temperature, the system is an aqueous polymer solution that easily entraps therapeutic payload Nov 1, 2023 · In situ gels have been developed for ocular use, with recent studies reporting the preparation of mucoadhesive ocular gels delivering itraconazole nanocrystals for the treatment of fungal keratitis [12] and a mucoadhesive in situ gel of Riluzole-loaded biodegradable nanoparticles optimized for treating the posterior eye segment [13]. g. Clinical studies should be the main focus of future research if the in situ gel is to significantly reduce periodontitis. Due to its special feature of ‘Sol to Gel transition’ it is widely accepted as a novel drug delivery system with improved patient compliance. In situ gelling system is a formulation that is in solution form before entering in to the body, but it ABSTRACT In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical applications due to its good biocompatibility, low The formation of in-situ gels depends on phase change system or sol-gel transition system. Considerable advances have been currently made in the development of novel formulations containing both natural and synthetic polymers. Its concentration and the iconic environment determine the gelling strength, elasticity, and stability, making it useful for controlled drug delivery on the ocular surface [6, 7]. -based in situ gels have potential to improve patient’s compliance by reducing the dosing frequency and could Key words: In situ gel, Ocular, Sulfacetamide sodium, Carbopol®/HPMC, In-vitro release, Antimicrobial eficacy. Aug 28, 2022 · In situ forming ophthalmic hydro-gels are liquid upon instillation undergoes phase transition in the ocular cul-de-sac to form visco elastic gel and this provides a response to environmental changes. Bioavail … Feb 2, 2025 · The topical administration of in situ hydrogels for ocular pathologies is a promising application strategy for providing high effectiveness and patient compliance. While designing an in situ gelling polymeric system, it is important to take drug release in account. In situ formation based on physiological stimuli: Thermally trigged system– Temperature-sensitive hydrogels are probably the most commonly studied class of environment-sensitive polymer systems in drug delivery research5. Designing of ocular drug delivery Apr 14, 2024 · In situ gel systems have emerged as promising drug delivery platforms due to their numerous benefits, including increased patient compliance and decreased administration frequency. In situ gel forming injectable drug delivery system is the ability to inject a drug incorporated into a polymer to a localized site and have the polymer form a semi-solid gel drug depot has a number of advantages. The various polymers helps in this Sep 10, 2020 · In situ gelling drug delivery systems have gained enormous attention over the last decade. Temperature-sensitive in situ gel containing 0. The in situ gel preparation is a safe and effective nasal delivery system for gastrodin. on instillation. Among the various gel types, hydrogels are particularly noteworthy for their extensive utilization in this domain. It involves the administration of drugs in a liquid form that transforms into a gel when it comes into contact with body fluids or temperature. , 2018). May 1, 2025 · Gels have gained significant prominence in pharmaceutical sciences due to their advantageous properties for drug delivery applications. Jul 12, 2020 · In situ gelling systems consist of polymers which are applied as solutions or suspensions that are capable of rapid sol-to-gel transformation triggered by external stimulus such as pH, temperature and ionic strength in the environment upon instillation [1]. ABSTRACT Over the past decade gel-based systems have emerged as a new approach to drug delivery system, attracting the interest of the scientific community. . Interestingly, these in situ gels not only improve postoperative tissue status but also release multiple drugs to combat residual tumor cells. Jan 1, 2016 · In situ gels are systems which are applied as solutions or suspensions and are capable of undergoing rapid sol-to-gel transformation triggered by external stimulus such as temperature, pH etc. It details the advantages, various methods of formulation, evaluation techniques, and specific applications of in situ gels across different medical contexts. Temperature-sensitive polymers, such as block copolymers or poloxamers, are frequently used to modify their gelation properties, usually in combination with other polymers. Oct 1, 2022 · The advantages of in-situ forming polymeric delivery systems, including simplicity of administration and reduced frequency of administration, increased patient compliance and comfort, have spurred attention. Preclinical reports from several researchers have proven that the delivery of drugs to the Thermosensitive mucoadhesive in situ forming oral gels are used to improve drug residence time at the site of action (Kapourani, 2023, Li, 2020, Wang, 2017). Applying a composite in situ thermoresponsive Approaches to enhance the nasal bioavailability aim at prolonging the contact time with the nasal surface by using viscosity-enhancing or in situ gelling polymers. In-situ is a Latin phrase which translated is literally as “in position”. Market Overview In situ gel drug delivery is a specialized drug delivery system that offers numerous advantages over traditional drug delivery methods. Dec 15, 2022 · This review on in situ gel was written to fill in any gaps in the current body of knowledge, with a special emphasis on in-situ gelling systems that prolong the residence time of drugs at their A variety of natural and synthetic polymers undergo in-situ gel formation and may be used in the oral, ocular, transdermal, buccal, intraperitoneal, parenteral, injection, rectal, and vaginal routes (3). The aim of the present study was to formulate and evaluate pH responsive in-situ gel for ophthalmic delivery. The prepared in situ gels were studied in the following aspects: in vitro gelation, in vitro release, stability, viscosity Jan 15, 2019 · In situ gel forming systems are drug delivery systems that are in solution form before administration in the body but once administered, undergo in situ gelation, to form a gel triggered by ABSTRACT: In situ gels are innovative drug delivery systems that transition from a liquid to a gel state in response to specific physiological conditions, such as changes in temperature, pH, or ionic strength. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug. , pH, temperature, and ionic concentration), in situ gelling systems quickly undergo a sol-gel phase transition into a viscoelastic gel. In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. Their biomedical application can further be improved by incorporating drug nanoparticles into in situ gelling systems in order Jul 18, 2024 · The ‘in situ gel’ system can be used to deliver both controlled and sustained delivery of drug. Different in-situ gel formulations of Cur were prepared using 30% of pluronic F127, and 1% of carbopol P934. Pre-formed hydrogels are basic viscous liquids that remain the same after delivery, while in situ gels are solutions or fluids that gel as a result of physicochemical changes after approaching the target site. Bioavailability, penetration, duration, and maximum medication efficacy are all improved by this Mar 5, 2024 · In-situ gel technology is a promising drug delivery strategy that undergoes a 'sol to gel' transition upon administration, providing controlled and prolonged drug release. A main component of these mucoadhesive drug delivery systems are Pluronics® (thermosensitive polymers), which are responsible for in situ gelation. These systems minimize drug administration frequency because of their special sol-to-gel transition properties, increasing patient comfort. Sep 1, 2004 · In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. Apr 20, 2021 · Meanwhile, suspensions are usually associated with drug non-uniformity and unpredictable ocular bioavailability compared with in situ gels [2, 4]. 1. Unlike very strong gels, these so-called in situ gelling polymers are simply delivered in liquid form to the site of drug absorption, which makes them a particularly favourable alternative to other polymers. The findings indicate that the elaborated thermosensitive niosomal in situ gels can be considered as a feasible platform for intravesical drug delivery. The “sol–gel” transition has distinct characteristics that respond to physiological stimulation, enabling a controlled and sustained drug release, thus offering various advantages over traditional mechanical and systemic drug delivery methods Feb 1, 2025 · These urgent clinical demands have inspired the development of in situ gels for topical administration in the resection cavity after surgical resection. The sol to gel transition occurs at various physiological conditions thereby provide sustained drug release. Recent advances in polymer chemistry and hydrogel engineering have facilitated the development of in situ forming hydrogels for drug delivery applications. Their biomedical application can further be improved by incorporating drug nanoparticles into in situ gelling systems in order to prolong Jan 24, 2025 · In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy in the local treatment of inflammatory and degenerative joint disease, such as In situ gel formulations represent a significant innovation in drug delivery systems. Th … Jan 1, 2016 · In the last decade in situ gelling systems have emerged as a novel approach in intranasal delivery of therapeutics, capturing the interest of scientific community. Dec 24, 2024 · Experimental data indicates that in situ gel forming systems may be helpful in treating a number of common oral cavity illnesses, according to the reviewed literature. The in situ gel has a numbers of merits and demerits that are enumerated below [1, 2]. The aim of the present investigation is to prepare and evaluate in situ gel-forming ophthalmic drug delivery system of moxifloxacin hydrochloride. Oct 23, 2023 · Background Ophthalmic in situ gel is a novel preparation. Nov 22, 2018 · Applications of in situ gel have been used for a variety of drug delivery routes, such as oral, ocular, rectal, vaginal and injection. Majority of polymers generally exhibit aqueous solubility on heating; nevertheless, many water soluble polymers precipitate out of solution. In-situ gel releases the drug sustainably maintaining the relatively constant plasma profiles respectively. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. The document reviews various polymer types and approaches Results: Herein, the authors focused on the current development of mucoadhesive gel systems used in buccal drug delivery. Mar 30, 2022 · The conducted microbial studies of selected niosomal in situ gels revealed the occurrence of a synergetic effect of the two compounds when simultaneously loaded. Sodium alginate, a novel ophthalmic gel-forming mucoadhesive polymer, which gets converted to gel in ABSTRACT This review on in situ gel was written to fill in any gaps in the current body of knowledge, with a special emphasis on in-situ gelling systems that prolong the residence time of drugs at their targets. As a new formulation, in-situ gel has become one of Sep 10, 2020 · In situ gelling drug delivery systems have gained enormous attention over the last decade. Mar 30, 2018 · In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. The in situ gelation mechanism has several advantages over ointments, the most notable being the ability to provide regular and continuous drug Aug 10, 2023 · In recent years, in situ gel delivery systems have received a great deal of attention among pharmacists. The purposes of this work are to investigate the release behavior in vitro and pharmacokinetic profiles in vivo of peptide and lowmolecular- weight hydrophilic drug loaded in the in situ gels. These are hydrogels that are liquid at room temperature and undergo gelation when in contact with body fluids or a change in pH. Jan 31, 2021 · Gels and in Situ Gelling Formulations for Drug Delivery Print Special Issue Flyer Special Issue Editors Special Issue Information Keywords Benefits of Publishing in a Special Issue Published Papers A special issue of Pharmaceutics (ISSN 1999-4923). Transition from sol to gel is contingent on one Sep 25, 2020 · A phospholipid-based phase separation in-situ gel (PPSG) system, which consists of phospholipids, medium chain oil (triglyceride) and ethanol as basic… Download Table | Marketed Products of ophthalmic In situ gels 47 from publication: Ocular in situ gel: An overview | Eye is the most sensitive organ of the body. ABSTRACT: In situ gel system has emerged as one of the best novel drug delivery system, it used for the sustained and controlled release of the drugs. This allows for sustained drug release. In situ, gelling is polymeric formulations that, although initially in sol form when ingested by the body, transform into gel forms when subjected to physiological circumstances. These gelation mechanisms are induced by environmental factors such as changes in pH, temperature, ion concentrations, or specific pH. In-situ gels are a type of hydrogel which are in In situ gels are now among the most widely used and widely available systems. State-of-the-art in situ gelling systems can easily and efficiently be formed by different mechanisms in situ. nanoparticles ocular tissues were employed to address issues related to represent promising drug carriers for targeting by remaining Jan 7, 2021 · In situ gels have become one of the most prominent and accessible systems. These formulations, which transition from a liquid to a gel or semi-solid state upon administration, offer enhanced bioavailability and controlled release profiles. [2]. By virtue of possessing stimuli-responsive phase transition properties, these systems can easily be administered into the eye, similar to normal eye drops. The use of biomaterial whose transitions from sol-gel is triggered by increase in temperature is an attractive way to approach in-situ formation. In situ gels are administered through various routes like oral, ocular, nasal, rectal, vaginal, i In situ forming polymeric formulations are drug delivery systems that are in sol form before being distributed in the body but gel in situ to create gel after being delivered. Jan 18, 2016 · In situ gel delivery systems are preferred over conventional systems due to sustained and prolonged release action of therapeutic payload onto the targeted site. Abstract In situ gelling drug delivery systems have gained enormous attention over the last decade. , 1974) for conformance control. Nov 8, 2022 · These gels are preferred over other stimuli-sensitive hydrogels since they have well-controlled in situ gelling properties and are also easier to load with drugs. This special issue belongs to the section "Physical Pharmacy and Formulation". In situ gels use polymers that undergo sol-gel transitions in response to temperature, pH, or ion changes. Mar 21, 2012 · Introduction: In situ gel systems refer to a class of novel delivery vehicles, composed of natural, semisynthetic or synthetic polymers, which present the unique property of sol–gel conversion o The document provides a comprehensive overview of in situ gels, a drug delivery system that transitions from solution to gel upon administration. In situ,gels undergo a phase transition from a liquid/ sol state to a gel state upon specific trigger or environmental conditions. In-situ gels are a type of hydrogel that starts off as a solution and gels when exposed to bodily fluids or changes in pH. This transition is triggered by physiological conditions such as pH, temperature, or the presence of specific Dec 9, 2024 · The “in situ gel” system has become one of the emerging drug delivery systems and plays a significant role in the treatment of periodontitis. 2. Gelation can be triggered by various stimuli, such as temperature, pH Mar 1, 2023 · In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in response to various stimuli such as changes in temperature, pH and ionic composition. The document discusses in situ gel drug delivery systems, which are liquid before administration but gel after contact with bodily fluids or tissues. The main body of the abstract Among drug delivery modalities, ocular drug administration requires careful study and parameter assessment. They swell at the drag absorption site to create a robust gel that can extend the active ingredient's residence duration. Recent advances in in-situ gels have made it possible to take advantage of changes in physiological uniqueness and in different areas of the gastrointestinal tract to improve drug absorption Sep 15, 2024 · The development of in situ gel formulations has gained prominence in pharmaceutical science due to their potential benefits in drug delivery and patient compliance. This review examines the key aspects of designing in situ oral Abstract In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. Sep 16, 2020 · Approaches, applications, and evaluation of in situ gels were explained with examples. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultraviolet irradiation, electrical sensitivity, enzyme sensitive from which drug get Meanwhile, suspensions are usually associated with drug non-uniformity and unpredictable ocular bioavailability compared with in situ gels [2, 4]. May 11, 2023 · The in situ ophthalmic gel is a semisolid ophthalmic preparation that can be changed in the eyes immediately after the solution is administered, showing unique advantages as a new drug delivery system. In-situ gels are a type of hydrogel which are in a solution form and are undergoes gelation under varying physiological conditions. Mar 5, 2024 · In-situ gel technology is a promising drug delivery strategy that undergoes a 'sol to gel' transition upon administration, providing controlled and prolonged drug release. Bhandwalkar and others published A review on in situ Nasal Gels for Nasal drug delivery system | Find, read and cite all the research you need on ResearchGate Feb 1, 2022 · In-situ gel treatment was developed in 1970s (Needham et al. Introduction In recent years, novel drug delivery systems have proven very adept at delivering therapeutic molecules with site-specific and localized effects. In situ administration of vaginal probiotics has been proposed as an effective prevention strategy against gynecological diseases caused by microecological disorders. Unlike conventional syrups, which remain in liquid form until they are consumed, in situ gel are designed to undergo a gelation process once ingested. Gellan gum, alginicacid INTRODUCTION: In situ is a Latin phrase which translated literally as “In position “. This study aimed to develop syringeable in-situ curcumin (cur) gel for the treatment of periodontal pockets as well as to evaluate the clinical efficacy of Cur in-situ gel formulation. This review presents the mechanism, recent development, and safety considerations of stimuli sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders. The formation of the gel depends on factors such as temperature fluctuations, pH changes, ion exposure and Nov 5, 2013 · Approaches to enhance the nasal bioavailability aim at prolonging the contact time with the nasal surface by using viscosity-enhancing or in situ gelling polymers. Recent advancements in in-situ hydrogels highlight their customizable properties, biomimetic designs, and responsive features, which enhance A notable advancement in drug delivery aiming to enhance patient safety and effectiveness is the development of the in situ nasal drug delivery system. Some of the therapeutics used to treat Jan 1, 2019 · Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. Such systems can be administered through different routes, to achieve local or systemic drug delivery In-situ gels are polymeric systems that undergo sol-to-gel transition upon contact with physiological fluids, making them an attractive drug delivery option for various applications. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. This review is to specify basic anatomy and physiology of eye, variousmethods for in situ gelling systems. Aug 10, 2023 · In recent years, in situ gel delivery systems have received a great deal of attention among pharmacists. This review article aims to provide an overview of the latest Mar 1, 2021 · Over the past decade gel-based systems have emerged as a new approach to drug delivery system, attracting the interest of the scientific community. Feb 1, 2025 · These urgent clinical demands have inspired the development of in situ gels for topical administration in the resection cavity after surgical resection. In-situ gel systems and their development have received considerable attention over the ages. Drugs with very short half-lives and high solubility are especially interested in in-situ gels. Within this system, drugs are initially administered as a less viscous solution, which upon contact with the nasal mucosa, transforms into a gel. Initially, these materials were formed outside of the patient and implanted Jul 1, 2024 · Another invention pertains to an aqueous in situ gel ophthalmic preparation comprising specific ingredients: a non-steroidal anti-inflammatory drug, a polysaccharide polymer exhibiting in situ gel characteristics, artificial tears, and water. Keywords: hydrogels, in situ gels, emulsion gels, microgels, nanogels, vesicular gels 1. The main objective is to formulate and evaluate in situ oral topical gels of clotrimazole based on the In situ gels are systems which are applied as solutions or suspensions and are capable of undergoing rapid sol-to-gel transformation triggered by external stimulus such as temperature, pH etc. Thermo-sensitive in situ gels are the most investigated gels since they are widely used as drug delivery systems. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Pharmacodynamic studies suggest that similar acesodyne and sedative effects were induced following intranasal administration of 50 mg/kg gastrodin nasal in situ gels or oral administration of 100 mg/kg gastrodin solution. In situ gelling agent is a polymeric formulation that are in sol-state prior to administration and its undergo gelation in to a body under physiological conditions and it has various factors to trigger the sol-gel transition such as temperature In situ gels-a xyloglucan: mucoadhesive 201 3;91: 618 in characterization Samanta MK, Raichur AM. Curcumin, a natural polyphenol, possesses all the prerequisites for successful therapy of ophthalmic diseases, but unfortunately its physicochemical properties hurdle the practical use. The concept of gel treatment is to improve the sweep efficiency of water flooding by placing a blocking slug of gel at water channel to seal the thief zone. Some of the therapeutics used to treat neurological diseases suffer from poor bioavailability. One such substance is myverol (glycerol mono-oleate), which is polar lipid that swells in water to form lyotropic liquid crystalline phase structures. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The incorporation of mucoadhesive polymers, additives and nanocarriers can further tune the properties of in situ gels as nasal delivery platforms. Gelation occurs due to cross linking of polymer chain through covalent and non-covalent bond formation [6]. This review focused on definitions, types, advantages, disadvantages, polymers used, and suitable characteristics of polymers, including the preparation of in situ gels covered in the introduction. Thermogel, a form of in situ gel-forming polymeric formulation, undergoes sol–gel transition after administration into the body. In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. This system is a liquid aqueous solution before the administration, and a gel at physiological conditions. This innovative approach provides controlled and sustained drug release, enhancing therapeutic Feb 1, 2025 · Gellan gum forms in-situ gels by transitioning from liquid to gel in response to temperature changes or the presence of ions like calcium. Various biodegradable polymers like gellan gum, pectin, alginic acid, chitosan, xyloglucan, etc are used. The main objective is to formulate and evaluate in situ oral topical gels of clotrimazole based on the concept of pH triggered and ion activated systems. These gels are composed of cross-linked 3D networks of polymers, with hydrogels being a specific type of absorbing water while retaining their shape. Approaches, applications, and evaluation of in situ gels were explained with examples. Administration route for in situ gel oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. In recent years, in situ gel delivery systems have received a great deal of attention among pharmacists. … Feb 26, 2021 · In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Common polymers for in situ gels include pectin, alginate, chitosan, and carbopol. Mechanisms of sol-gel formation for niosomal in- situgel can vary depending on the specific formulation and the stimuli used. This review summarizes advances in in situ gels for nasal drug delivery. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied to the site. mgke mbyeot gwe teeoi mhl swuwnzq suz lhaw olcm mkoowib